I'd print out the PDF on paper and then transfer it to metal. You can cut it by hand, but it would take a long time. A drill press and a hole saw can get it done. It will just take a long time.

Alternatively, you can take that DXF file and contact some local laser, plasma cutter, or waterjet manufacturers and see if they can make one for you. Someone could also cut it mostly by hand for a cheaper amount with a plasma cutter or just an oxy torch.